The guide on four weeks on semaglutide with no weight loss specifically addresses early non-response, while tirzepatide not working anymore addresses the scenario where effects diminish over time
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The nervous system can quickly develop tolerance to the drug
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Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)