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Sampling variability of liver biopsy in nonalcoholic fatty liver disease
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2000;279(3):E501 to 507
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The phase 3 RCT of oral semaglutide add-on therapy evaluating the efficacy and safety of oral semaglutide in T2D subjects with moderate renal impairment (PIONEER-5) 49 demonstrated significantly greater HbA1c improvement compared with placebo of 0.8% and weight reduction of 2.5 kg
Having reviewed the literature and talked to 5+ individuals who have taken semaglutide, two downsides emerge: The weight will very likely come back on if you discontinue usage It is very difficult to maintain muscle mass while on these drugs Two images summarize these issues
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