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(3) Clinical Gaps : While preclinical data (e.g., berberines 500 mg/kg dose in rats) are promising, human trials are sparse, with only cinnamon, coffee, and wheat fiber tested in modest cohorts

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10.1161/HYPERTENSIONAHA.110.168344 237

Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation