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This has been hypothesized to result from aspirin-induced inhibition of urate reabsorption (aspirin inhibiting a different urate transporter involved in reabsorption) in the proximal tubule (Figure 2)

Potential side effects are usually associated with higher doses and may include mild digestive issues, especially when starting supplementation

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[7] PharmaCotherapia d.o.o., Phase I, Pilot Study in Healthy Volunteers, to Assess the Safety and Pharmacokinetics of PCO-02, Which Active Ingredient is BPC-157, a Penta-deca-peptide From Gastric Source., clinicaltrials.gov, Clinical trial registration NCT02637284, Dec

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The peptides for gut health resource provides additional context on how intestinal peptide therapy can influence systemic health outcomes