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The two agents work on different receptor systems amylin receptors and GLP-1 receptors respectively producing additive weight loss that exceeds what either drug achieves alone

Onset can occur within hours of combination dosing or after weeks of chronic co-administration the threshold is not reliably predictable from either compounds individual safety profile

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R.ColucciS

Since plasma glucocorticoid levels are normal and their rate of metabolism is increased, total daily metabolism and excretion of 17-ketosteroids and 17 hydroxy-corticoids are usually increased (419, 420)