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Batch correction and dimensionality reduction Batch correction was performed across samples to correct for technical variability between samples and to integrate the samples into a single dataset using the fastMNN function from the Batchelor R package (Haghverdi et al

In this instance, GSA was performed to quantify the influence of all model parameters on model OCR output (Fig

Melatonin treatment significantly reduced KLRG1 expression, further indicating a shift away from a pathogenic effector state ( Supplementary Figures 4G )