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When NAD availability is high, metabolic pathways function smoothly

However, in a recent study published in Nature Metabolism, a team of researchers from the UF College of Pharmacy, Florida State University and University College in London found the gut and brain GLP-1 systems do not interact

This raises an intriguing question of whether alternative sources of energy, such as ketone bodies by-passing the glycolytic pathway, might lead to increases in energy, and indeed some studies showed a reduction in fatigue in ME/CFS on a ketone diet [80]

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[DOI] [PubMed] [Google Scholar] Haorah J, Rump TJ, Szlachetka A (2009) Mechanism of alcoholinduced mitochondrial dysfunction in the brain: implication for neurodegeneration

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