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Obesity classes (adult, per NHLBI): Class 1 obesity: BMI 30.034.9 Class 2 obesity: BMI 35.039.9 Class 3 obesity (morbid/severe): BMI 40.0 Pediatric obesity is defined differently

medication alone rarely sustains long-term weight control

Whether restoring youthful GHK-Cu levels would have clinically meaningful effects on aging is speculative

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Because body composition, eating patterns, and health behaviors differ around the world, the authors emphasized the need to understand how these drugs work in more diverse populations

53 In both Phase 1a and 1b trials, it has been established that orforglipron does not have food or water administration restrictions and may provide a safe and effective oral treatment option for patients with T2D and other indications