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Pharmaceutics 16 , 561572 (2019)

Arazi, A

When your skin stretches suddenly, the middle layer of the skin breaks in places, allowing the deeper layers to show through

This pattern is reported across forums and is consistent with IGF-1's known effects on intracellular hydration and protein synthesis through PI3K/Akt/mTOR (Yoshida & Delafontaine, 2020)

The results were striking: 53.5% of the treated patients achieved a complete response on the Fatigue Severity Scale, indicating a total resolution of their severe fatigue, compared to merely 3.5% in the untreated control group