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Due to its large molecular weight and quaternary charge, it is not absorbed across the lining of the GI tract if taken orally, as might happen if one were to consume the meat from an animal shot with a curare-poisoned-tip arrow

PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta

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[DOI] [PubMed] [Google Scholar] 39.Boozer CN, Leibel RL, Love RJ, Cha MC, Aronne LJ

Rather than functioning as isolated antioxidant modules, these pathways form a highly interconnected redox buffering network in which compensatory capacity, metabolic flux, and iron availability collectively determine ferroptotic susceptibility