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Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) for in situ analysis of endogenous small molecules in biological samples

2003 Nov;20(6):560-1

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Medication Response and Receptor Dynamics While true pharmacological tolerance to GLP-1 receptor agonists appears limited based on current evidence, individual variation in receptor expression, desensitization patterns, and downstream signaling may influence long-term response

[9] However, meta-analyses have called these conclusions into question, [10] highlighting methodological problems showing no difference from a placebo, and lack of support from larger scale trials

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