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Lgr5 + stem cells divide into proliferating transit-amplifying (TA) cells, each of which can differentiate into either a secretory or absorptive progenitor cell

Gastrointestinal disorders, primarily nausea, were the most common treatment-emergent adverse events, which could be mitigated with slower dose escalation

These effects explain both their potential benefits and many of their common gastrointestinal side effects

Accessed August 17, 2023.

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What if my side effects don't improve after 4 weeks