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This, in turn, triggers the HIF1A (hypoxia inducible factor 1 subunit alpha)-dependent Warburg effect and AIM2 (absent in melanoma 2)-dependent inflammasome activation, contributing to Kras G12D -induced pancreatic tumorigenesis [212]

Pregnant individuals, those with a personal history of pancreatitis triggered by GLP-1 use, and patients on incompatible medications should discuss alternatives with their provider

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In the Type I syndrome patients have hypoparathyroidism, muco-cutaneous candidiasis, Addison's disease, and occasionally hypothyroidism