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These included amyotrophic lateral sclerosis (ALS), pulmonary fibrosis (PF), acute respiratory distress syndrome (ARDS), Duchenne muscular dystrophy (DMD), cystic fibrosis (CF), Huntingtons disease (HD), pulmonary hypertension (PH), cytokine release syndrome (CRS), frontotemporal dementia (FTD), and graft-versus-host disease (GVHD)., All selected diseases were confirmed to be classified as rare diseases by Orphanet ( a widely used global database for rare diseases

Within the CNS, hindbrain GLP1 neurons project to numerous brain regions relevant to metabolic regulation in mice (Figure 1) (Burcelin et al., 2009

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