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The dose you are given, how frequent and for how long depends on what you are being treated for and your doctors recommendations

An 8-week placebo-controlled trial in healthy adults demonstrated reductions in exercise-induced oxidative stress and enhancement of endogenous antioxidant enzyme activities

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However, other studies have shown a negative impact on sperm motility and morphology with anti-retroviral treatments

This article explains the concept of relative rest within the bigger scheme of recovering from sports injuries in some detail