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GLP-1R is chiefly sorted either towards lysosomal degradation or recycled back to the plasma membrane, with the balance between the two predictive of insulinotropic efficacy of biased agonists (Jones et al., 2018b)

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As an alternative substrate for creatine kinase (CPK) [43], in GAMT and CRTR deficiency, GAA phosphate [44] provides an alternative high-energy reservoir to replace creatine phosphate, thus preventing myopathy