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Step 2: 5 hours prior to the colonoscopy, but no sooner than 4 hours from starting dose Repeat all of Step 1 with the second dose.

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To obtain monomeric fractions, SEC was performed on a Superdex 200 Increase 10/300 GL Column (Cytiva), as described above 97

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Dysesthesia, defined as an altered skin sensation often described as sensitivity, pain, or burning, occurred significantly more frequently at the higher dose (22.9% versus 6.0%)