Temperature fluctuation, heat, humidity, and light exposure
According to the FDA's approval, the eligibility criteria are as follows: For Adults: A Body Mass Index (BMI) of 30 kg/m or greater (defined as obesity), OR a BMI of 27 kg/m or greater (defined as overweight) with at least one weight-related comorbidity, such as high blood pressure, type 2 diabetes, or high cholesterol
Note that there are drugs in development as sub-cutaneous (SC) administration (like current Ozempic, Wegovy, Zepbound, Mounjaro), whilst we wont need to wait to long for the oral versions of these drugs to come out (next 6-12 months)
Early research, including a study from Tokyo Medical University, reported modest weight reduction in participants supplementing with this strain over a 12-week period
Reconstituted solutions are generally stable for 4 to 6 weeks under proper refrigeration
However, these do have to be prescribed and administered by a healthcare professional, and are more likely to be given to people who have lifelong conditions affecting their ability to absorb B12 or who are at higher risk of consistent deficiency