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This condition requires lifelong intramuscular vitamin B12 therapy to prevent serious neurological complications

Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a potent hepatocyte growth factor (HGF) receptor agonist originally developed at Washington State University

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Day 1: 500mg or 1000mg NAD IV (2.5-5 hrs) Day 4: 100mg NAD SQ Day 6: 100mg NAD SQ Daily: 250mg NR/NMN in the morning Week 8 NR/NMN has a dose-response curve but also hits a plateau

Comparison with CRH-induced corticotropin and cortisol secretion Biologial Psychiatry, 1988 Jun, Volume 24 (Issue 2), Pages 162-72