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It donates methyl groups to synthesize creatine, carnitine, and phosphatidylcholine while also serving as a precursor to glutathione, the body's primary intracellular antioxidant

Fink RG

By-products of oxygen metabolism, physiological functions of the free radicals and antioxidant mechanisms are concisely explained

Therapies targeting endothelial dysfunction, such as phosphodiesterase-5 inhibitors and endothelin receptor antagonists, have shown efficacy in improving hemodynamics and symptoms in PAH patients ( Inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and monocyte chemoattractant protein-1 (MCP-1) are elevated in PAH, contributing to endothelial damage and vascular remodeling ( Oxidative stress plays a critical role in the pathogenesis of PAH, primarily through its effects on endothelial dysfunction, vascular remodeling, and cellular metabolic reprogramming

Gnzler WA, Steffens GJ, Grossmann A et al (1984) The amino-acid sequence of bovine glutathione peroxidase

Hortic Res