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F1000Res 9 , F1000 (2020)

Rare but serious risks include pancreatitis, gallbladder disease, and a thyroid C-cell tumor risk based on rodent studies (semaglutide carries a boxed warning and is contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2)

Let's be absolutely clear about that

Injectable therapies inherently carry risks that necessitate professional oversight

Additionally, repackagers should ask the manufacturer about the intended use of the ingredient

Given that the nomogram cannot be safely used for risk assessment in MR and ER overdose, it is unclear whether the documented risks for MR acetaminophen extend to the ER formulation