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In 1997, our comparative analysis of ligand-containing and ligand-free forms of human -fetoproteins by several techniques including DSC revealed the release of ligands converted this protein into the molten globular form, which was evidenced by the absence of any visible heat absorption in the DSC thermograms and high C p values (Uversky et al., 1997)

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J Clin Sleep Med (2018) 14:16371

This is experimental territory, and treating it otherwise would be irresponsible