In vitro experiments have shown that GSH deficiency induced by either the siRNA approach or pharmacological inhibition of the GCL rate-limiting enzyme decreases GSH biosynthesis and escalates oxidative stress in cultured hepatocytes
Eating smaller, healthier meals supports appetite control and enhances weight loss
While pharmacotherapy may delay surgery, it does not replace its role in adolescents with severe obesity and comorbidities
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This is an autosomal recessive disorder, meaning that two mutations are necessary to have the severe disorder
However, darker pigmentation does not equal complete photoprotection
