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Nabi R, Alvi SS, Shah A, Chaturvedi CP, Iqbal D, Ahmad S, et al
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Based on REDEFINE trial populations and the NDA submission terms, expected eligibility criteria are: BMI 30 , or BMI 27 with at least one weight-related condition such as hypertension, dyslipidemia, type 2 diabetes, or obstructive sleep apnea Adults 18 years or older Not pregnant or breastfeeding Contraindications will likely include: personal or family history of MTC or MEN 2 syndrome, prior serious allergic reaction to semaglutide or cagrilintide, and active pancreatitis
Peptide therapy typically requires ongoing or periodic treatment to maintain benefits
The higher concentration often enables faster healing timelines compared to standard dosing