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Inversely, it is not possible to discount a role for an enzyme on the basis of lack of induction

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The best course of treatment for melasma would be sun avoidance, using a mineral-based sunscreen combined with topical skincare products with hydroquinone, Retinoids, Vitamin C, Kojic Acid, Niacinamide, Alpha Hydroxy Acids, Beta Hydroxy Acids, Azelaic Acid, and Arbutin

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