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Side effects (gastrointestinal: nausea, vomiting, diarrhea) are similar to injectable GLP-1 therapies

Moderate caloric restriction: A deficit of 500-750 calories below measured resting metabolic rate (obtained via indirect calorimetry) produces predictable weight loss of 1-1.5 pounds per week without triggering the metabolic adaptation that accompanies very low-calorie diets

Compounded Semaglutide is not recommended for individuals who: Potential Side Effects These side effects are usually mild and may improve over time: Serious Side Effects (Seek Medical Attention If You Experience These) GLP-1s are most effective for adults with a BMI of 27 or higher (with weight-related health conditions) or BMI of 30 or higher