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other changes are subtle, slow, and only obvious once you look back

Octreotide (MW 1019 Da) offered the advantage of a relatively small increase in stability in intestinal fluid afforded by a macrocycle backbone, two D-amino acids, and a modified C terminus, 11 whereas semaglutide remained unstable in the GI tract despite being stable in plasma due to affinity of its fatty acid chains for albumin

10.1042/cs20160343 Clin

doi: 10.1161/circulationaha.107.739938 83 BoseAKMocanuMMCarrRDYellonDM

doi: 10.1186/s12974-024-03118-3, 54 ErolU.SatarB.KozanS.AtesK.TorunD.GoksoyC.et al

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