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This increases the sensitivity to chemotherapy in gastric cancer cells, and offers a novel treatment strategy for advanced gastric cancer and chemotherapy resistance

NAD also plays significant role in gene expression linked to age-related diseases

Among the newer approaches gaining traction

doi: 10.3389/fchem.2025.1536858 Received 29 November 2024 Accepted 27 January 2025 Published 19 March 2025 Volume 13 - 2025 Edited by Federica Aureli, National Institute of Health (ISS), Italy Reviewed by Eric Deconinck, Sciensano (Belgium), Belgium Maria Cristina Gaudiano, National Institute of Health (ISS), Italy Updates Copyright 2025 Blazewicz, Poplawska, Daniszewska, Piorunska and Karynski

[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy

& Rinaldi, B