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The body is forced to switch to inefficient, anaerobic (oxygen-free) energy production, which generates lactic acid and further exacerbates systemic pain and fatigue

For these experiments, cells were seeded at the same density (12,992 cells per cm 2 ) in both the bottom well and the insert

Therefore, fatigue could possibly be relieved by restoring serum carnitine levels through supplementation 641

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Measurement of plasma parameters Similar to the clinical data from patients with obesity [38], MC4R KO mice showed significantly increased levels of markers of liver injury, including AST, ALT, TC, and TG (Fig