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This may reflect a rapid cellular uptake of the TAT-GFP fusion protein, leading to low detectable concentrations in the bloodstream despite its effective distribution in peripheral tissues

Mol Microbiol 93:346355 Consortium TU (2024) UniProt: the universal protein knowledgebase in 2025

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Br J Haematol 91(1):234-44, 1995

Its most clinically noticeable early effect for most patients is improved sleep quality and morning energy, driven by pineal gland stimulation and melatonin normalization, typically visible within weeks two to three