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Pivotal trials: what the NEJM data show Semaglutide STEP-1 (2021) and SELECT (2023) STEP-1 (Wilding et al., NEJM 2021) randomized 1,961 adults over 68 weeks on semaglutide 2.4 mg/week
The Lilly testing found impurities from a chemical reaction between tirzepatide and B12 with unknown safety profiles
In the following post, Ill explain how GLP-1 medications (like Ozempic, etc.) work and highlight some potential areas of concern
Importantly, seizures are not listed as an adverse reaction in the SmPC, and no signal of lowered seizure threshold has been identified in clinical trials or post-marketing surveillance to date
Our team at JosephCareRX emphasizes the importance of monitoring, education, and ongoing support