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(ii) improvement in insulin sensitivity, where and indices improve through the combined effects of weight loss and adipose tissue redistribution (78)

Tuxhorn JA, Ayala GE, Rowley DR

After assessing the early deficits of both motor and cognitive traits in a behavioural test battery (Morris water maze, novel object discrimination, rotarod, feet clasping, spontaneous activity), we classified the R6/1 mice in 'good', 'bad' and 'normal' performers according to their scores in the tests