Drinking more water, eating fiber-rich foods, eating smaller meals, and staying active can ease constipation and other gastrointestinal symptoms
10.1074/jbc.M602799200
Population-based surveys from the United States estimate lifetime kratom use at approximately 0.71.3% of adults, with self-reported motivations most commonly including chronic pain relief (4866%), management of mood or anxiety symptoms (1222%), and self-treatment of opioid withdrawal or substance dependence (820%) [1, 2, 5, 6]
The downsides are obvious
The combination of actions facilitates weight loss and increases glycemic control
So people with diabetes, we already know, don't lose as much weight with incretin-based treatments like semaglutide or other, actually any other antiobesity drugs