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In the development of the GLP-1 receptor agonist, semaglutide, the strategy used to extend the drugs half-life was to promote covalent and non-covalent binding of semaglutide to albumin through the addition of a fatty-acid attachment on semaglutide

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Statistical analysis Statistical analysis was performed by parametric one-way analysis of variance, with post-hoc Newman-Keuls test and non-parametric Kruskal-Wallis test and subsequently the Mann-Whitney U test to compare groups