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While labeled as stem cells owing to their multipotential capacities, the use of MSCs in cell therapies is primarily focused on their ability to migrate to sites of injury or inflammation within the body and to modulate immune responses and stimulate tissue regeneration through their secretion of bioactive factors and via cellcell interactions (Caplan, 2017

doi: 10.1210/endocr/bqaf028

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222,223 The activation of mTORC1 versus mTORC2 is context-dependent and regulated by upstream signaling dynamics and subcellular localization

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