For some people, increasing the dose helps restart progress
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The tumour incidence was 11% at the highest dose compared with 2% in vehicle controls (Dunkelberg, 1981)
2 In addition to lifestyle modifications (diet and exercise), many pharmacologic strategies have been proposed to counter iatrogenic weight gain, including appetite suppressants (eg, pro-dopaminergic agents such as phentermine, stimulants, and amantadine), pro-anorectant anticonvulsants (eg, topiramate or zonisamide), opioid receptor antagonists (eg, olanzapine/samidorphan or naltrexone) and oral hypoglycemics such as metformin
The former is a calculated risk that many researchers accept with the understanding that BUDs include a safety margin
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