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Ortiz-Munoz G, Houard X, Martin-Ventura JL, Ishida BY, Loyau S, Rossignol P, Moreno JA, Kane JP, Chalkley RJ, Burlingame AL, Michel JB, Meilhac O

Six RCTs [13, 18, 3235] involving 406 patients provided low certainty evidence (Table 2) that L-carnitine supplementation significantly changes (reduced) in the AST levels (MD: 15.89, 95%CI: 29.87 to 1.91) and low certainty evidence (Table 2) that L-carnitine supplementation significantly changes (reduced) in the ALT levels (MD: 26.38, 95%CI: 45.46 to 7.30)

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Vargas et al., 2005)

In summary, mTOR inhibitors have revealed disease-modifying potential in cancer and genetic disorders such as TSC, but their use is limited by metabolic toxicity

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