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In preclinical models it is studied for its effect on appetite signalling, energy expenditure and fat-mass reduction, which is why physique and weight-management researchers track it so closely

It launched under the brand name Mounjaro for diabetes management in 2022 and Zepbound for weight loss in 2023

Link to the FDA's statement in comments

If the "King Kong" shot does become available, that might be enough horsepower to treat the most severe obesity cases

Gutzwiller JP, Tschopp S, Bock A, et al

Investigators have suggested that this rate is partly explained by patients reaching weight loss thresholds at which they themselves chose to discontinue [10]