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Doxorubicin, on the other hand, generates free radicals, causing intracellular oxidative damage and further activating apoptotic signaling pathways [470, 471]

The groundwork laid during these weeks determines later success

Patients should be informed of the pros and cons of oral versus parenteral therapy, and regardless of the form of treatment, those with pernicious anemia or malabsorption should be reminded of the need for lifelong replacement

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Topical applications deliver the ingredient directly to skin cells, though absorption can be limited by the molecule's size and stability