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Combinational therapy of a VEGFR1 and VEGFR2 peptide-based vaccine with S-1 plus cisplatin provided higher clinical efficacy, and no severe adverse effects were reported in patients with advanced gastric cancer

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This phenomenon is associated with uncoupled mitochondrial respiration, elevated proton leak, ROS formation, cellular apoptosis, and, more important, increased myocardial oxygen consumption (56)

The most common abused stimulant by athletes is amphetamine