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although less potent than Erastin in vitro , its feasibility for systemic dosing and observed ferroptosis linked sensitization in difficult models underscore its translational relevance (84)

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These results suggest that PGE2-induced EC activation may occur through the EP4/AC/cAMP/PKA pathway, which mediates GRK2 translocation to the cell membrane, not the GRK2 mRNA expression level, and the reduction of the inhibitory effect of GRK2 on ERK1/2