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The same signaling that quiets the upper digestive tract also reduces the pace of movement further down, which gives the colon more time to reabsorb water from stool, and stool that is drier and slower moving is simply harder to pass

Nature (1996) 379:6972

In addition to the aforementioned remodelling of the metabolome in fatigue-associated diseases, including long COVID, acylcarnitines have emerged as important modulators of CNS function [29]: In both mice and humans, different classes of acylcarnitines have been found to be altered in either mouse models of depression or humans with MDD, with associations to symptom severity and also treatment response, as reviewed by Liu et al

kidney problems (swelling, urinating less, feeling tired or short of breath)

Others may find it difficult, even when use creates medical risks

If you get nauseous easily or have GI issues, start here