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After 3 months, women who increased FV intake by 3 or more servings experienced significant improvements in insomnia-related sleep difficulties compared to those with no change or a decrease in FV intake [147]

200 mg doses have been used and cumulative doses as high as 1000 mg have been given

However, these medications have limitations

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To limit potentially life-threatening depletion of intracellular antioxidant/GSH stores, epithelial cells have developed numerous compensatory pathways, including the cystine-glutamate antiporter (SLC7A11), which critically maintains de novo GSH biosynthesis by increasing intracellular cystine levels (9)