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The loss of dopaminergic signaling also leads to increased glutamatergic activity, which may contribute to neuronal excitability and worsen symptoms

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As a result, compounded semaglutide may have inconsistencies in dosage, effectiveness, and safety, potentially introducing harmful impurities or inaccurate dosing

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6, Supplementary Figs S6 and S7, Table 3), although the bias towards calcium mobilisation was less apparent for the pGLP-1 at the human receptors (Fig