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Under pathological conditions, the mitochondrial electron transport chain causes the formation of large amounts of ROS

While both compounds interact with GLP-1 and GIP pathways, Retatrutide differs as a triple agonist involving glucagon receptor activity

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Importantly, it is the NRF2-KEAP1 interaction that creates a sensitive intracellular sensor system for oxidative stress, that can also be manipulated by electrophiles