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Severe or prolonged B12 deficiency can lead to a range of neurological manifestations, including peripheral neuropathy, which may present as pain, paraesthesia (pins and needles), or altered sensation in the extremities

Insulin-like growth factor 1 (IGF-1): a growth hormone

Its unique structure allows it to support healing at the cellular level, making it a popular choice for recovery and gut health support

Other reactions warranting urgent GP contact include: Unexplained muscle weakness or cramping Persistent vomiting or severe abdominal pain Signs of hypokalaemia (low potassium) during initial treatmentmuscle weakness, irregular heartbeat, or severe fatigue In patients with severe, longstanding B12 deficiency, rapid correction can occasionally precipitate hypokalaemia as new red blood cells are produced, consuming available potassium

Used together and under medical supervision, semaglutide and B12 may support broader metabolic health markers over time, including waist circumference and cardiovascular risk factors, alongside your overall sense of well-being

Get the details in the B-12 section of our B Vitamin Supplements Review