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Economic Analysis Method Patients and Databases Population-based administrative databases for Ontario were used to identify patients receiving vitamin B12 (cobalamin) intramuscular injections in any fiscal year between 2006 and 2011

While convenient, the bioavailability may be lower compared to injections

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Adenosylcobalamin facilitates a complex biochemical reaction that converts L-methylmalonyl-CoA into succinyl-CoA

In silico molecular docking further supports this, showing that Epitalon has a high binding affinity for specific histone subtypes, H1/3 and H1/6, which play a regulatory role in chromatin compaction and accessibility [4]

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