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Raun and colleagues characterised it as the first selective growth hormone secretagogue: it released GH from rat pituitary cells with potency and efficacy similar to GHRP-6, but unlike GHRP-6 and GHRP-2, both of which raised ACTH and cortisol ipamorelin did not release ACTH or cortisol at levels significantly different from GHRH stimulation, even at doses more than 200-fold above its ED50 for GH release [7]

When these fusions are present, immunohistochemistry using antibodies directed toward the kinase domain demonstrates staining in all the melanocytes of the Spitz nevus, demonstrating that the Spitz nevus is a clonal proliferation of a melanocyte transformed by the fusion

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1999 Jun;5(2):200201