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If SG and related therapeutics blunt voluntary physical activity via motivational suppression, dampened reward processing, or attenuation of habitual exercise, this could have unintended consequences for long-term energy expenditure, weight maintenance, and preservation of fat-free mass

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In summary, as time progresses and systems improve, the number of ADE reports for semaglutide may increase, and its safety signal spectrum may continually evolve

Shockingly, well start with a broad overview

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GLP1RAs reduce caloric intake and body weight, improve insulin sensitivity, and favorably modulate adipose tissue and systemic inflammation [10,12]