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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

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53 Interestingly, studies suggest male infertility (except in cases that can be attributed to obstruction) may be an early sign of cancer, other impending disease, and death

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doi:10.36740/WLek202211224 Romero-Cabrera JL, Ankeny J, Fernandez-Montero A, Kales SN, Smith DL

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